UT Health San Antonio Institutional Core Laboratories

The mission of the Advanced Cytometry and Sorting Facility (ACSF) is to provide expert support to MD Anderson researchers using flow cytometry and cell sorting technologies.

The Advanced Microscopy Core specializes in fluorescence microscopy modes such as super-resolution, confocal and dynamic microscopy and provide the instrument access, training, expertise and collaboration to researchers .

The Advanced Technology Genomics Core provides researchers with a comprehensive range of genomic services, that includes next generation sequencing, Sanger sequencing, gene resequencing, single cell analysis, microarrays, droplet digital PCR, NanoString analysis and fluorescent fragment analysis

The AIM Shared Resource provides expertise in the science of collecting and managing patient-reported outcome data, assessing energy balance, and developing and implementing technology applications for behavioral assessment and intervention.

The mission of the Bionutrition Research Core is to facilitate state-of-the-art nutritional science research by providing the resources, expertise, and infrastructure necessary to conduct controlled human feeding studies and dietary intervention, accurately assess participants' diets

The Biospecimen Extraction Resource provides a centralized laboratory for standardized, high quality DNA, RNA and protein extraction from blood, tissues, saliva, cells, or other patient derived biospecimens.

The Bone Histomorphometry Core Laboratory provides histomorphometric analyses of nondecalcified bone specimens, including processing mouse bone specimens for nondecalcified histology and performing static and dynamic histomorphometric analyses of mouse bone specimens.

The primary goal of this facility is to offer conventional and molecular cytogenetic services, including species identification, karyotyping, analysis of genomic instability, fluorescence in situ hybridization and spectral karyotyping

The Shared Decision Making Core (SDM Core) provides researchers with access to decision science expertise and state-of-the-art methods necessary to develop, evaluate, and disseminate SDM interventions to enhance the quality of cancer care delivery at MD Anderson and its partner institutions.

The Flow Cytometry and Cell Imaging Core Facility at Science Park provides cutting edge cell analysis resources. These include cell sorting and analytical flow cytometry to phenotype, quantify and isolate cells and confocal microscopy to capture high resolution images.p

The EpiCore is a unique facility and a comprehensive one-stop-shop for the expertise, methods and services to assess epigenome, and provides a valuable resource for first time and established investigators to continue their research in epigenetics.

The Functional Genomics Core provides researchers with genetic tools for studying and annotating gene functions in cell-based assays, including human and mouse shRNA, human ORF (Open Reading Frames) and human CRISPR/Cas9 libraries

The GEMF generates mouse models for MD Anderson Cancer Center members and offers essential services for archiving important mouse models and rederiving novel models from outside sources.

The mission of the High Resolution Microscopy Facility is to provide scanning and transmission electron microscopy services to researchers.

Laboratory Animal Genetic Services (LAGS) provides cost-effective, customized genome scans using polymorphic genetic markers (SSLPs and SNPs) to support speed congenic line development and background strain characterization for mice and rats

TThe Metabolomics Core provides state-of-the-art, ultra-high resolution mass spectrometry platforms capable of measuring thousands of metabolites and lipids in biological matrices of all types (e.g., cells, media, tissues, whole blood, plasma, urine)

The Monoclonal Antibody Facility develops high quality, cost effective customized MAbs to meet the basic, translational, and clinical research needs of MD Anderson investigators.

The FCCIF specializes in single cell technologies including FACS Cell Sorting, Analytical Flow Cytometry, Multispectral Flow Cytometry, Suspension Mass Cytometry, Imaging Mass Cytometry, Confocal Imaging, Live Cell Imaging, Multispectral Imaging, and High-plex Tissue Imaging,.

The NMR facility is used for structure determination of compounds developed in drug discovery, pharmacology, and diagnostic imaging laboratories.

The ORION core provides state-of-the-art immunoprofiling services including clinical trial immune monitoring, data analysis and technical consultation for assay design, as well as single service instrument use.

Performs high-throughput microarray services for genotyping, gene expression and methylation profiling; facilitates population genomic studies by providing controlled access to archived blood biospecimens

The Proteomics Facility provides state-of-the-art mass spectrometry analysis of proteins for both basic and clinical cancer research

Functional Proteomics Reverse Phase Protein Array RPPA Core provides cancer center members with access to a powerful, highthroughput, quantitative costeffective antibodybased assay to characterize basal or ligandinduced protein expression and modification, and timeresolved responses appropriat

RHCL provides high-quality routine and specialized histology services including histochemical stains, processing of non-decalcified bone samples and advanced applied technologies such as Tissue microarray construction, IHC, CISH, Digital slide scanning, Digital image analysis and pathology ser...

The Small Animal Imaging Facility provides access to imaging instrumentation and expertise that allows researchers to integrate powerful and cutting edge imaging technologies into routine preclinical research with confidence that their scientific objectives will be achieved.

The Protein Array and Analysis Core (PAAC) provides research tools for the discovery and characterization of novel protein-protein interactions that drive signal transduction pathways.

The Cell Analysis Core provides centralized services, training, access and support to researchers in the usage of flow cytometry and confocal microscopy equipment and related services including technical training opportunities.

The Genomics Core performs fee-for-service sample processing for any nucleic acid Next Generation Sequencing (NGS) application (genome, transcriptomes, epigenome, etc.). Particular expertise in bacterial genome assembly and mammalian single-cell genomics.

KAMC is a state-of-the-art electron microscopy and advanced characterization core facility housed at the University of Texas at San Antonio. The center supports world-class research in nanotechnology, biology, chemistry and materials sciences.

The Proteomics and Protein Biomarkers Core Facility is focused on capillary liquid chromatographymass spectrometry LCMS and tandem mass spectrometry LCMSMS to identify, characterize, and quantify proteins.

The Stem Cell Core provides access to a streamlined, IRB-approved consenting process for acquisition of patient samples and generation of pluripotent stem cells and stem cell-derivatives for basic and preclinical research.

The BioScope™ II microscope has been engineered to facilitate advanced life science research such as imaging, probing and manipulating biological systems at the nanometric scale. We can determine the micromechanical properties of both biological and non-biological samples.

We offer services to researchers, including access to clinical data and enhanced subject recruiting, and are involved in multiple local and national collaborations with other groups.

The CTC is an FDA registered facility where tissues are processed to produce cells for clinical applications. It is focused on translating, validating and supporting IND applications at a preclinical level into clinical grade processes.

The Center for Advanced Microscopy provides assisted or unassisted state of the art imaging capabilities including three confocal microscopes, fluorescence lifetime imaging, live animal imaging with an IVIS Lumina, flow cytometry, and a liquid handling multiwell plate reader.

The Flow Cytometry Service Center provides a broad range of assisted and unassisted flow cytometry services from basic single color analysis to advanced 14 parameter analysis and multi population cell sorting.

The MR group provides advanced MRI techniques, including selective tissue imaging, magnetic resonance spectroscopic imaging, diffusion tensor imaging to neurological disorders, central nervous system trauma, and drug addiction both in humans and animal models.

The CTPC services provided are designed to identify and quantitate proteins and their modifications in a broad range of research specimens from simple purified protein samples to biomarker discovery and verification in complex mixtures such as cell and tissue extracts, plasma andor other biofluids

Lab offers Luminex bead array, HTP pyrosequencing, and WES capillary Westerns. Single cell analysis include: immunofluorescence micromanipulator manual single cell isolation, DEPArray automated single cell isolation, Biomark microfluidic PCR, laser capture microdissection and atomic force microscopy

We offer service in Biobanking including subject consenting, phlebotomy. biospecimen processing/storage, and isolation of nucleic acides, Digital Pathology scanning with a Leica Aperio Versa 200 and real-time PCR analyses of DNA copy number and gene expression with a Bio-rad CFX96/384 Touch System and a QS200 Droplet Digital PCR system.

The lab can sort all NIH-designated biohazard 2 agents. Core personnel are trained and certified in proper BSL-2 safety procedures. The lab has 1 cell sorters 16-parameter FACSAria-IIIu; and 4 cell analyzers: 64-detector Cytek Aurora Spectral analyzer, 13-parameter LSR-II, 14-parameter FACSCelesta.

DLAR provides husbandry, veterinary care and management of research colony animals plus technical support for experimental surgery, anesthesia & post-surgical care. The Veterinary staff provides consultation, collaboration and assistance with animal model and written protocol development.

The lab has multiple modern mass spectrometers. Protein analysis services include molecular mass determination, protein identification, sequence and post-translational modification site characterization. Quantitative analysis of lipids and intermediary metabolites by GC/MS is also available.

Broad spectrum of modern optical imaging systems: confocal/multiphoton microscopy, wide-field microscopy, fluorescence lifetime imaging microscopy, fluorescence spectral imaging, super-resolution and whole-animal imaging. High-temporal resolution imaging of rapid events in living cells is available.

We offer services to generate knockout/knock-in mouse lines by CRISPR genome editing in mouse zygotes, including designing, on/off-targeting mutagenesis genotyping services; as well as cryopreservation of mouse embryos/sperm, rederivation, IVF, and mouse colony expansion.

State-of-the-art Bruker spectrometers equipped with high sensitivity cryoprobes operating at 500, 600, and 700 MHz. The instruments provide full capabilities for modern NMR experiments with 15N, 13C, and 2H labeled macromolecules and are suitable for obtaining three-dimensional solution structures.

The Research Histopathology Core is equipped with the latest available instrumentation. RHC’s instrumentation is operated by highly skilled personnel available to assist in tissue preparation, immunohistochemistry, immunofluorescence, Insitu hybridization, including assay optimization, image anal...